Insights on the evidence of cardiotoxicity of hydroxychloroquine prior and during COVID-19 epidemic.
Identifieur interne : 000C70 ( Main/Exploration ); précédent : 000C69; suivant : 000C71Insights on the evidence of cardiotoxicity of hydroxychloroquine prior and during COVID-19 epidemic.
Auteurs : Serena Romani [France] ; Alexandre Gérard [France] ; Audrey Fresse [France] ; Delphine Viard [France] ; Élise Van-Obberghen [France] ; Joëlle Micallef [France] ; Fanny Rocher [France] ; Milou-Daniel Drici [France]Source :
- Clinical and translational science [ 1752-8062 ] ; 2020.
Abstract
The recent empirical use of hydroxychloroquine in coronavirus disease 2019 (COVID-19) revived the interest in its cardiac toxicity, increasingly sidelined over time. We aimed to assess and compare the profile of cardiac adverse drug reactions (CADR) associated with hydroxychloroquine before and during COVID-19. We performed a retrospective comparative observational study using the French Pharmacovigilance network database between 1985 and May 2020 to assess all postmarketing CADR associated with hydroxychloroquine notified before COVID-19 in its approved indications for lupus and rheumatoid arthritis (preCOV), and those concerning its empirical use in COVID-19 (COV). Eighty-five CADR in preCOV were compared to 141 CADR in COV. The most common CADR of preCOV were cardiomyopathies (42.4%) and conduction disorders (28.2%), both statistically more frequent than in COV (P<0.001). COV notifications significantly highlighted repolarization and ventricular rhythm disorders (78.0%, P<0.001) as well as sinus bradycardias (14.9%, P= 0.01) as compared with preCOV. Estimated incidence of CADR was significantly higher among patients exposed to off-label use of hydroxychloroquine in COVID-19 (2.9%) than before COVID-19 in its approved indications (0.01%, P<0.001). The use of hydroxychloroquine in COVID-19 sheds a new light on the spectrum of its cardiac toxicity. This fosters the value of a closer monitoring of all patients treated with hydroxychloroquine, regardless of its indication, and the importance of an update of its summary of product characteristics.
DOI: 10.1111/cts.12883
PubMed: 32964653
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Insights on the evidence of cardiotoxicity of hydroxychloroquine prior and during COVID-19 epidemic.</title><author><name sortKey="Romani, Serena" sort="Romani, Serena" uniqKey="Romani S" first="Serena" last="Romani">Serena Romani</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Gerard, Alexandre" sort="Gerard, Alexandre" uniqKey="Gerard A" first="Alexandre" last="Gérard">Alexandre Gérard</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Fresse, Audrey" sort="Fresse, Audrey" uniqKey="Fresse A" first="Audrey" last="Fresse">Audrey Fresse</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Viard, Delphine" sort="Viard, Delphine" uniqKey="Viard D" first="Delphine" last="Viard">Delphine Viard</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Van Obberghen, Elise" sort="Van Obberghen, Elise" uniqKey="Van Obberghen E" first="Élise" last="Van-Obberghen">Élise Van-Obberghen</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Micallef, Joelle" sort="Micallef, Joelle" uniqKey="Micallef J" first="Joëlle" last="Micallef">Joëlle Micallef</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of clinical Pharmacology and Pharmacovigilance, Aix Marseille Univ, APHM, INSERM, Inst Neurosci Syst, UMR 1106, 254 rue St Pierre, 13005, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of clinical Pharmacology and Pharmacovigilance, Aix Marseille Univ, APHM, INSERM, Inst Neurosci Syst, UMR 1106, 254 rue St Pierre, 13005, Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Rocher, Fanny" sort="Rocher, Fanny" uniqKey="Rocher F" first="Fanny" last="Rocher">Fanny Rocher</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Drici, Milou Daniel" sort="Drici, Milou Daniel" uniqKey="Drici M" first="Milou-Daniel" last="Drici">Milou-Daniel Drici</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32964653</idno><idno type="pmid">32964653</idno><idno type="doi">10.1111/cts.12883</idno><idno type="wicri:Area/Main/Corpus">000033</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000033</idno><idno type="wicri:Area/Main/Curation">000033</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000033</idno><idno type="wicri:Area/Main/Exploration">000033</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Insights on the evidence of cardiotoxicity of hydroxychloroquine prior and during COVID-19 epidemic.</title><author><name sortKey="Romani, Serena" sort="Romani, Serena" uniqKey="Romani S" first="Serena" last="Romani">Serena Romani</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Gerard, Alexandre" sort="Gerard, Alexandre" uniqKey="Gerard A" first="Alexandre" last="Gérard">Alexandre Gérard</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Fresse, Audrey" sort="Fresse, Audrey" uniqKey="Fresse A" first="Audrey" last="Fresse">Audrey Fresse</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Viard, Delphine" sort="Viard, Delphine" uniqKey="Viard D" first="Delphine" last="Viard">Delphine Viard</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Van Obberghen, Elise" sort="Van Obberghen, Elise" uniqKey="Van Obberghen E" first="Élise" last="Van-Obberghen">Élise Van-Obberghen</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Micallef, Joelle" sort="Micallef, Joelle" uniqKey="Micallef J" first="Joëlle" last="Micallef">Joëlle Micallef</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of clinical Pharmacology and Pharmacovigilance, Aix Marseille Univ, APHM, INSERM, Inst Neurosci Syst, UMR 1106, 254 rue St Pierre, 13005, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of clinical Pharmacology and Pharmacovigilance, Aix Marseille Univ, APHM, INSERM, Inst Neurosci Syst, UMR 1106, 254 rue St Pierre, 13005, Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Rocher, Fanny" sort="Rocher, Fanny" uniqKey="Rocher F" first="Fanny" last="Rocher">Fanny Rocher</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Drici, Milou Daniel" sort="Drici, Milou Daniel" uniqKey="Drici M" first="Milou-Daniel" last="Drici">Milou-Daniel Drici</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author></analytic><series><title level="j">Clinical and translational science</title><idno type="eISSN">1752-8062</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The recent empirical use of hydroxychloroquine in coronavirus disease 2019 (COVID-19) revived the interest in its cardiac toxicity, increasingly sidelined over time. We aimed to assess and compare the profile of cardiac adverse drug reactions (CADR) associated with hydroxychloroquine before and during COVID-19. We performed a retrospective comparative observational study using the French Pharmacovigilance network database between 1985 and May 2020 to assess all postmarketing CADR associated with hydroxychloroquine notified before COVID-19 in its approved indications for lupus and rheumatoid arthritis (preCOV), and those concerning its empirical use in COVID-19 (COV). Eighty-five CADR in preCOV were compared to 141 CADR in COV. The most common CADR of preCOV were cardiomyopathies (42.4%) and conduction disorders (28.2%), both statistically more frequent than in COV (P<0.001). COV notifications significantly highlighted repolarization and ventricular rhythm disorders (78.0%, P<0.001) as well as sinus bradycardias (14.9%, P= 0.01) as compared with preCOV. Estimated incidence of CADR was significantly higher among patients exposed to off-label use of hydroxychloroquine in COVID-19 (2.9%) than before COVID-19 in its approved indications (0.01%, P<0.001). The use of hydroxychloroquine in COVID-19 sheds a new light on the spectrum of its cardiac toxicity. This fosters the value of a closer monitoring of all patients treated with hydroxychloroquine, regardless of its indication, and the importance of an update of its summary of product characteristics.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32964653</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1752-8062</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Sep</Month><Day>10</Day></PubDate></JournalIssue><Title>Clinical and translational science</Title><ISOAbbreviation>Clin Transl Sci</ISOAbbreviation></Journal><ArticleTitle>Insights on the evidence of cardiotoxicity of hydroxychloroquine prior and during COVID-19 epidemic.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/cts.12883</ELocationID><Abstract><AbstractText>The recent empirical use of hydroxychloroquine in coronavirus disease 2019 (COVID-19) revived the interest in its cardiac toxicity, increasingly sidelined over time. We aimed to assess and compare the profile of cardiac adverse drug reactions (CADR) associated with hydroxychloroquine before and during COVID-19. We performed a retrospective comparative observational study using the French Pharmacovigilance network database between 1985 and May 2020 to assess all postmarketing CADR associated with hydroxychloroquine notified before COVID-19 in its approved indications for lupus and rheumatoid arthritis (preCOV), and those concerning its empirical use in COVID-19 (COV). Eighty-five CADR in preCOV were compared to 141 CADR in COV. The most common CADR of preCOV were cardiomyopathies (42.4%) and conduction disorders (28.2%), both statistically more frequent than in COV (P<0.001). COV notifications significantly highlighted repolarization and ventricular rhythm disorders (78.0%, P<0.001) as well as sinus bradycardias (14.9%, P= 0.01) as compared with preCOV. Estimated incidence of CADR was significantly higher among patients exposed to off-label use of hydroxychloroquine in COVID-19 (2.9%) than before COVID-19 in its approved indications (0.01%, P<0.001). The use of hydroxychloroquine in COVID-19 sheds a new light on the spectrum of its cardiac toxicity. This fosters the value of a closer monitoring of all patients treated with hydroxychloroquine, regardless of its indication, and the importance of an update of its summary of product characteristics.</AbstractText><CopyrightInformation>This article is protected by copyright. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Romani</LastName><ForeName>Serena</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gérard</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fresse</LastName><ForeName>Audrey</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viard</LastName><ForeName>Delphine</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van-Obberghen</LastName><ForeName>Élise</ForeName><Initials>É</Initials><AffiliationInfo><Affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Micallef</LastName><ForeName>Joëlle</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Pharmacovigilance, Department of clinical Pharmacology and Pharmacovigilance, Aix Marseille Univ, APHM, INSERM, Inst Neurosci Syst, UMR 1106, 254 rue St Pierre, 13005, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rocher</LastName><ForeName>Fanny</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drici</LastName><ForeName>Milou-Daniel</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Pharmacovigilance, Department of Clinical Pharmacology, Université Côte d'Azur Medical Center, Pasteur hospital, Bât J4, 30, avenue de la Voie-Romaine, CS51069, 06001, Nice Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>French Pharmacovigilance Network</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Transl Sci</MedlineTA><NlmUniqueID>101474067</NlmUniqueID><ISSNLinking>1752-8054</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID‐19</Keyword><Keyword MajorTopicYN="N">ECG</Keyword><Keyword MajorTopicYN="N">QTC interval</Keyword><Keyword MajorTopicYN="N">adverse drug reactions</Keyword><Keyword MajorTopicYN="N">cardiology</Keyword><Keyword MajorTopicYN="N">cardiovascular risk</Keyword><Keyword MajorTopicYN="N">hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">ion channels</Keyword><Keyword MajorTopicYN="N">pharmacovigilance</Keyword><Keyword MajorTopicYN="N">phase IV</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>23</Day><Hour>6</Hour><Minute>43</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32964653</ArticleId><ArticleId IdType="doi">10.1111/cts.12883</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li><li>Nice</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Romani, Serena" sort="Romani, Serena" uniqKey="Romani S" first="Serena" last="Romani">Serena Romani</name></region><name sortKey="Drici, Milou Daniel" sort="Drici, Milou Daniel" uniqKey="Drici M" first="Milou-Daniel" last="Drici">Milou-Daniel Drici</name><name sortKey="Fresse, Audrey" sort="Fresse, Audrey" uniqKey="Fresse A" first="Audrey" last="Fresse">Audrey Fresse</name><name sortKey="Gerard, Alexandre" sort="Gerard, Alexandre" uniqKey="Gerard A" first="Alexandre" last="Gérard">Alexandre Gérard</name><name sortKey="Micallef, Joelle" sort="Micallef, Joelle" uniqKey="Micallef J" first="Joëlle" last="Micallef">Joëlle Micallef</name><name sortKey="Rocher, Fanny" sort="Rocher, Fanny" uniqKey="Rocher F" first="Fanny" last="Rocher">Fanny Rocher</name><name sortKey="Van Obberghen, Elise" sort="Van Obberghen, Elise" uniqKey="Van Obberghen E" first="Élise" last="Van-Obberghen">Élise Van-Obberghen</name><name sortKey="Viard, Delphine" sort="Viard, Delphine" uniqKey="Viard D" first="Delphine" last="Viard">Delphine Viard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C70 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C70 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32964653
|texte= Insights on the evidence of cardiotoxicity of hydroxychloroquine prior and during COVID-19 epidemic.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32964653" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidFranceV1
| This area was generated with Dilib version V0.6.37. |  |